Lyrica Medication Nerve Pain
Lyrica was originally FDA approved as an anti-epileptic drug, also called an anticonvulsant. It works by slowing down impulses in the brain that cause. Pregabalin also affects chemicals in the brain that send pain signals across the nervous system.Lyrica is used to treat pain caused by, or nerve pain in people with diabetes (diabetic neuropathy), (post-herpetic ), or spinal cord injury.Lyrica may also be used for purposes not listed in this medication guide. Important InformationLyrica can cause a severe allergic reaction. Stop taking this medicine and seek emergency medical help if you have or blisters on your skin, trouble breathing, or swelling in your face, mouth, or throat.Some people have thoughts about suicide while taking Lyrica. Stay alert to changes in your mood or symptoms.
Pamelor (nortriptyline HCl) and Lyrica (pregabalin) are used to treat neuropathic (nerve) pain. Pamelor is used off-label for nerve pain. Pamelor is primarily used to treat depression. Lyrica is also used to treat partial onset seizures in adults and to treat fibromyalgia. Elavil (amitryptiline) and Lyrica are used to treat nerve pain. Skate it soundtrack. Elavil is also used to treat depression and mood disorders. Elavil may also be used to treat other conditions including eating disorders, anxiety, and panic disorders. Lyrica is also used for treating partial onset seizures in adults and fibromyalgia.
Report any new or worsening symptoms to your doctor.If you have diabetes or heart problems, call your doctor if you have weight gain or swelling in your hands or feet while taking Lyrica.Do not stop using this medicine suddenly, even if you feel fine. Stopping suddenly may cause withdrawal symptoms.Do not change your dose without your doctor's advice. Tell your doctor if the medication does not seem to work as well in treating your condition. See also:(in more detail) What happens if I miss a dose?Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.
What happens if I overdose?Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. What should I avoid while taking Lyrica?Avoid drinking alcohol.
It may increase certain side effects of Lyrica.Avoid driving or hazardous activity until you know how this medicine will affect you. Your reactions could be impaired. Lyrica side effectsLyrica can cause a severe allergic reaction. See also:(in more detail) What other drugs will affect Lyrica?Using Lyrica with other drugs that slow your breathing can cause dangerous side effects or death.
Ask your doctor before using opioid medication, a sleeping pill, cold or allergy medicine, a muscle relaxer, or medicine for anxiety or seizures.Tell your doctor about all your other medicines, especially:.oral diabetes medicine -,; or.an ACE inhibitor -, or.any other seizure medicationsThis list is not complete. Other drugs may interact with pregabalin, including prescription and over-the-counter medicines,. Not all possible drug interactions are listed here.
Generic name: PREGABALIN 25mg
Dosage form: capsule, oral solution
See also:
Medically reviewed by Drugs.com. Last updated on Aug 28, 2019.
- Dosage
Important Administration Instructions
LYRICA is given orally with or without food.
When discontinuing LYRICA, taper gradually over a minimum of 1 week [see Warnings and Precautions (5.3)].
Because LYRICA is eliminated primarily by renal excretion, adjust the dose in adult patients with reduced renal function [see Dosage and Administration (2.7)].
Neuropathic Pain Associated with Diabetic Peripheral Neuropathy in Adults
The maximum recommended dose of LYRICA is 100 mg three times a day (300 mg/day) in patients with creatinine clearance of at least 60 mL/min. Begin dosing at 50 mg three times a day (150 mg/day). The dose may be increased to 300 mg/day within 1 week based on efficacy and tolerability.
Although LYRICA was also studied at 600 mg/day, there is no evidence that this dose confers additional significant benefit and this dose was less well tolerated. In view of the dose-dependent adverse reactions, treatment with doses above 300 mg/day is not recommended [see Adverse Reactions (6.1)].
Postherpetic Neuralgia in Adults
The recommended dose of LYRICA is 75 to 150 mg two times a day, or 50 to 100 mg three times a day (150 to 300 mg/day) in patients with creatinine clearance of at least 60 mL/min. Begin dosing at 75 mg two times a day, or 50 mg three times a day (150 mg/day). The dose may be increased to 300 mg/day within 1 week based on efficacy and tolerability.
Patients who do not experience sufficient pain relief following 2 to 4 weeks of treatment with 300 mg/day, and who are able to tolerate LYRICA, may be treated with up to 300 mg two times a day, or 200 mg three times a day (600 mg/day). In view of the dose-dependent adverse reactions and the higher rate of treatment discontinuation due to adverse reactions, reserve dosing above 300 mg/day for those patients who have on-going pain and are tolerating 300 mg daily [see Adverse Reactions (6.1)].
Adjunctive Therapy for Partial-Onset Seizures in Patients 1 Month of Age and Older
The recommended dosages for adults and pediatric patients 1 month of age and older are included in Table 1. Administer the total daily dosage orally in two or three divided doses as indicated in Table 1. In pediatric patients, the recommended dosing regimen is dependent upon body weight. Based on clinical response and tolerability, dosage may be increased, approximately weekly.
| Age and Body Weight | Recommended Initial Dosage | Recommended Maximum Dosage | Frequency of Administration |
|---|---|---|---|
| Adults (17 years and older) | 150 mg/day | 600 mg/day | 2 or 3 divided doses |
| Pediatric patients weighing 30 kg or more | 2.5 mg/kg/day | 10 mg/kg/day (not to exceed 600 mg/day) | 2 or 3 divided doses |
| Pediatric patients weighing less than 30 kg | 3.5 mg/kg/day | 14 mg/kg/day | 1 month to less than 4 years of age: 3 divided doses 4 years of age and older: 2 or 3 divided doses |
Both the efficacy and adverse event profiles of LYRICA have been shown to be dose-related.
The effect of dose escalation rate on the tolerability of LYRICA has not been formally studied.
The efficacy of adjunctive LYRICA in patients taking gabapentin has not been evaluated in controlled trials. Consequently, dosing recommendations for the use of LYRICA with gabapentin cannot be offered.
Management of Fibromyalgia in Adults
The recommended dose of LYRICA for fibromyalgia is 300 to 450 mg/day. Begin dosing at 75 mg two times a day (150 mg/day). The dose may be increased to 150 mg two times a day (300 mg/day) within 1 week based on efficacy and tolerability. Patients who do not experience sufficient benefit with 300 mg/day may be further increased to 225 mg two times a day (450 mg/day). Although LYRICA was also studied at 600 mg/day, there is no evidence that this dose confers additional benefit and this dose was less well tolerated. In view of the dose-dependent adverse reactions, treatment with doses above 450 mg/day is not recommended [see Adverse Reactions (6.1)].
Neuropathic Pain Associated with Spinal Cord Injury in Adults
The recommended dose range of LYRICA for the treatment of neuropathic pain associated with spinal cord injury is 150 to 600 mg/day. The recommended starting dose is 75 mg two times a day (150 mg/day). The dose may be increased to 150 mg two times a day (300 mg/day) within 1 week based on efficacy and tolerability. Patients who do not experience sufficient pain relief after 2 to 3 weeks of treatment with 150 mg two times a day and who tolerate LYRICA may be treated with up to 300 mg two times a day [see Clinical Studies (14.5)].
Dosing for Adult Patients with Renal Impairment
In view of dose-dependent adverse reactions and since LYRICA is eliminated primarily by renal excretion, adjust the dose in adult patients with reduced renal function. The use of LYRICA in pediatric patients with compromised renal function has not been studied.
Base the dose adjustment in patients with renal impairment on creatinine clearance (CLcr), as indicated in Table 2. To use this dosing table, an estimate of the patient's CLcr in mL/min is needed. CLcr in mL/min may be estimated from serum creatinine (mg/dL) determination using the Cockcroft and Gault equation:
Next, refer to the Dosage and Administration section to determine the recommended total daily dose based on indication, for a patient with normal renal function (CLcr greater than or equal to 60 mL/min). Then refer to Table 2 to determine the corresponding renal adjusted dose.
(For example: A patient initiating LYRICA therapy for postherpetic neuralgia with normal renal function (CLcr greater than or equal to 60 mL/min), receives a total daily dose of 150 mg/day pregabalin. Therefore, a renal impaired patient with a CLcr of 50 mL/min would receive a total daily dose of 75 mg/day pregabalin administered in two or three divided doses.)
For patients undergoing hemodialysis, adjust the pregabalin daily dose based on renal function. In addition to the daily dose adjustment, administer a supplemental dose immediately following every 4-hour hemodialysis treatment (see Table 2).
| Creatinine Clearance (CLcr) (mL/min) | Total Pregabalin Daily Dose (mg/day)* | Dose Regimen | |||
|---|---|---|---|---|---|
| TID= Three divided doses; BID = Two divided doses; QD = Single daily dose. | |||||
| |||||
| Greater than or equal to 60 | 150 | 300 | 450 | 600 | BID or TID |
| 30–60 | 75 | 150 | 225 | 300 | BID or TID |
| 15–30 | 25–50 | 75 | 100–150 | 150 | QD or BID |
| Less than 15 | 25 | 25–50 | 50–75 | 75 | QD |
| Supplementary dosage following hemodialysis (mg)† | |||||
| Patients on the 25 mg QD regimen: take one supplemental dose of 25 mg or 50 mg | |||||
| Patients on the 25–50 mg QD regimen: take one supplemental dose of 50 mg or 75 mg | |||||
| Patients on the 50–75 mg QD regimen: take one supplemental dose of 75 mg or 100 mg | |||||
| Patients on the 75 mg QD regimen: take one supplemental dose of 100 mg or 150 mg | |||||
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Related questions
More about Lyrica (pregabalin)
- During Pregnancy or Breastfeeding
Consumer resources
Other brands:Lyrica CR
